Symbol
Name
ID

Lrp2
low density lipoprotein receptor-related protein 2
MGI:95794

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Aplasia/Hypoplasia of the corpus callosum	Agenesis of corpus callosum	Partial agenesis of the corpus callosum	Intellectual disability	Global developmental delay	Seizure
Disease(s) Associated with LRP2
Donnai-Barrow syndrome

Mouse Phenotypes

nervous system phenotype

abnormal embryonic neuroepithelium morphology

delayed neural tube closure

abnormal brain morphology

abnormal forebrain development

small embryonic telencephalon

holoprosencephaly

abnormal lateral ventricle morphology

abnormal choroid plexus morphology

choroid plexus hyperplasia

absent corpus callosum

abnormal forebrain morphology

abnormal diencephalon morphology

abnormal telencephalon morphology

abnormal cerebral cortex morphology

abnormal olfactory bulb morphology

absent olfactory bulb

small olfactory bulb

abnormal cerebellum fissure morphology

exencephaly

abnormal dendrite morphology

decreased retina ganglion cell number

abnormal retina bipolar cell morphology

abnormal optic nerve morphology

Availability

Mouse Genotype

Lrp2^27SH/Lrp2^27SH

Lrp2^m267Asp/Lrp2^m267Asp
Tg(Rr291-lacZ)#Mekk/0

Lrp2^m267Asp/Lrp2^m267Asp

Lrp2^tm1Her/Lrp2^tm1Her

Lrp2^tm1Tew/Lrp2^tm1Tew

Foxg1^tm1(cre)Skm/Foxg1⁺
Lrp2^tm1Tew/Lrp2^tm1Tew (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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